Expression of HER2/neu and Ki-67 in
Urothelial Carcinoma and their Relation to
Clinicopathological Data: An Egyptian Study
Published: March 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/45922.14624
Badawia B Ibrahim, Samira A Mahmoud, Alzahraa A Mohamed, Hala M El hanbuli
1. Professor, Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
2. Professor, Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
3. Assistant Lecturer, Department of Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
4. Assistant Professor, Department of Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Correspondence
Dr. Hala M El Hanbuli,
Department fo Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
E-mail: Hmh06@fayoum.edu.eg
Introduction: Bladder cancer is the most common malignancy involving the urinary system and the ninth most common malignancy worldwide. Ki-67 is a nonhistone cellular marker for proliferation. HER2/neu is an oncogene that plays an important role in the pathogenesis of many cancer types. In bladder carcinoma, its clinical significance remains under-investigated and poorly linked to the patients’ clinicopathological features especially with no reported Egyptian study.
Aim: The aim of this work was to study the expression of HER2/ neu and Ki-67 in urinary bladder carcinoma to evaluate their role in tumourigenesis and their correlation with other available clinicopathological variables associated with urothelial carcinoma.
Materials and Methods: This cross-sectional study was conducted at the Department of Pathology, Faculty of Medicine, Cairo University, Egypt. Samples were paraffin blocks from 60 cases diagnosed with urothelial carcinoma underwent radical cystectomy. Ki-67 and HER2/neu immunohistochemical staining was done and of Ki-67 and HER2/NEU Immunostaining was recorded. The associations between Ki-67, HER2/neu expressions and clinical and histopathological parameters of urothelial bladder carcinoma was evaluated.
Results: The Ki-67 expression had significant association with tumour histological grade and lymphovascular invasion (p-value <0.05). The association of HER2/neu expression had significant association with perineural invasion (p-value <0.05).
Conclusion: HER2/neu immunostaining was not associated with most of the clinicopathologic prognostic factors in urothelial bladder carcinoma.
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